Top1 releases torsional stress during DNA replication and transcription in actively proliferating cells 1. Owing to the high proliferative rate of cancer cells, Top1 inhibitors have long been ...
A topoisomerase enzyme discovered more than a decade ago in an archaeal microorganism turns out to be distinct, both structurally and mechanistically, from any other known topoisomerase. Only four ...
Hormonal treatment of endometrial stromal sarcomas (ESS): A possible indication for aromatase inhibitors No standard treatment is established for patients with advanced soft tissue sarcoma after ...
The COVID-19 pandemic has now entered its eighth month, but severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to spread in many parts of the world. Researchers are still ...
Leishmania, a unicellular kinetoplastid protozoan parasite, is the causative agent of leishmaniasis. With the spread of human immunodeficiency virus (HIV), the parasites pose a much greater threat ...
This fundamental role in cell life makes topoisomerase I an important target for cancer therapies: its inhibition leads to DNA strand breaks, preventing the replication of diseased cells. This ...
Women can be identified as being at increased risk for recurrence after primary surgery for breast cancer by a variety of pathologic factors including number of axillary lymph nodes involved with ...
Scientists at Charles University and Mayo Foundation for Medical Education and Research (MFMER) have synthesized DNA topoisomerase II β inhibitors reported to be useful for the treatment of ...
In this paper, we show that hyperthermia suppresses the level of topoisomerase mediated single- and double-strand breaks induced by exposure to topoisomerase poisons. A new paper, High Temperature ...
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